Hhv-8 :: essays research papers

humans Herpes Virus-8 (HHV-8) and Kaposis Sarcoma (KS)Human herpes virus (HHV-8) poses a challenging task for researchers determining its single-valued function in Kaposis sarcoma (KS). People with KS atomic number 18 distinguished by their view in four categories. The first category consists of elderly males of Mediterranean or Eastern European Jewish descent. The twinkling category consists of individuals of all ages from Africa. incomplete one of these categories is associated with immune deficiency or known environmental instruments. The stand firm two categories argon associated with organ transplants or HIV-1. In all forms of KS males are predominantly affected.Kaposis Sarcomas are known to harbor cellular phones known as spindle shaped cells (SC). The spindle shaped cells are associated with abnormal declivity vessel development and blood leakage. Although, the SC is the most frequently encountered cell in KS tumors it is undetermined if they are neoplastic cells or hyperproliferating cells or an adapted cell induced by cytokines (INF-&61543).Although, it is easy to believe that all cells in a tumor are neoplastic, evidence suggests otherwise. There are third characteristics that are present in all KS cells whether they are neoplastic or not. The first is absence of a histologically distinguishable neoplastic cell. The second is the lack of usual chromosomal abnormalities. The last is a combination of three features angiogenesis, inflammation, and proliferation.The one doer that brings the four categories of people infected with KS is HHV-8 found in KS tissues. Although, HHV-8 is thought to be connected to KS, HHV-8 itself has very low risk factor for KS development. Most reports on KS indicate a 2% to 10% preponderance of HHV-8 in the world, but in the U.S. there is thought to be a 5% prevalence among men according to a 1970s baseline incidence of KS. In relation to HIV-1 incidence of KS increases by a factor of 20,000 to 50,000 times wit h the presence of HHV-8.It is postulated that HIV-1 infections promote HHV-8 replication indirectly by suppression of host immune systems. KS is thought to begin with micro-vascular lesions mediated by antithetical environmental factors for each of the four categories of KS. One of these factors is abnormal cytokine production in HIV-1 associated KS, this includes an increase in inflammatory cytokines, such as IFN &61543, TNF &61537, and IL-7 that are enhanced by Tat of HIV-1. Tat which is essential for HIV-1 replication is released and interpreted up by other cells, where it inhibits T-cell proliferation and promotes abnormal cytokine production, adhesion, and growth.